Gene mutation CCR5-D32
Has anyone heard about this?
With the gene mutation of CCR5-D32, protects t-cells from HIV.
So would people infected with the HIV given blood transfusion or a bone marrow transplant with this gene mutation basically dormant the HIV virus? Thus curing from all aliments from HIV and/or AIDS.
Welcome to A2A, brutetal. Thanks for the link - I had heard of this but didn't know the details.
The article says "In 2008, German doctors announced that an HIV-infected leukemia patient had received a bone marrow transplant from a donor who is homozygous for the CCR5-Δ32 trait. After 600 days, the patient was healthy and had undetectable levels of HIV in the blood and in examined brain and rectal tissues. Before the transplant, low levels of HIV X4, which does not use the CCR5 receptor, were also detected. Following the transplant, however, this type of HIV was not detected either, further baffling doctors.". I doubt that any of us would be able to add to that.
Thanks, but why hasn't it made public or gone into further research by the major teams that are funded to find the cure for aids?
Like no one knows about this, when there is a possible cure to it.
Even if it means a higher chance to be infected with the West Nile Virus.
I have often wondered why subjects like this aren't more announced to the public.
Just like I read a couple years ago how a dentist found an enzyme thats active in the mouth that actually attacks and kills the HIV virus. This same enzyme is found throughout the body but is in an inactive form. The government bought the research and I've never heard anything more about it. The dentist stated that if they could find a way to active the enzyme in the rest of the body that it could very well be a cure to HIV/AIDS.
There have been a lot of major break throughs on both the cure and vaccine fronts.
How much you want to bet it's something similar to the movie Outbreak?
The government, seeing as they own the research, etc., or at the very least, will, wants to wait until there's [more of an] epidemic [then there already is]. It'll make them look like heroes, having a vaccine prepared 2 years before the fact, letting countless people die.
I'm such a thorn.0
<b>Nothing's perfect... The world's not perfect. But it's there for us, trying the best it can. That's what makes it so damn beautiful.</b> <br /><...
Scientific research is a slow process, and often (indeed, usually) things that look promising in early tests either don't work on further testing, or turn out to have serious problems. For this reason most scientists are cautious about public announcements.
However, anyone can search the professional medical literature through PubMed. A quick search reveals that this gene mutation is an active area of research - see for example this paper.
Eddie, I'm doubtful about that story of the dentist. I'm not sure what would be meant by "the government bought the research", unless it meant they bought patent rights. There have been many myths about magnificent inventions that have supposedly been bought in order to suppress them (ignoring the fact that patents are public documents, and patent protection has a limited lifetime) - perhaps this is another one?
Quote:Eddie, I'm doubtful about that story of the dentist. I'm not sure what would be meant by "the government bought the research", unless it meant they bought patent rights. There have been many myths about magnificent inventions that have supposedly been bought in order to suppress them (ignoring the fact that patents are public documents, and patent protection has a limited lifetime) - perhaps this is another one?
The article was in a science/medical Journal so I doubt it was fictitious, though I will say I am not sure what was meant when it stated that the government bought the research. It’s been a good 2-3 years when I read the article. My brain starts to get a bit fuzzy after all that time LoL
I tried to do some quick google research but couldn't find much, but did find:
Quote:Saliva is also one of your body's main defenses against disease-causing organisms, such as bacteria and viruses. It contains antibodies that attack viral pathogens, such as the common cold and HIV.
Article found Here If nothing else its a good article about oral health
I think I may have found it: was it "Endogenous salivary inhibitors of human immunodeficiency virus" (1999)? Or perhaps "Parotid salivary basic proline-rich proteins inhibit HIV-I infectivity" (2001)?
Some other notable papers on the topic:
Secretory leukocyte protease inhibitor (SLPI): oxidation of SLPI does not explain its variable anti-HIV activity (1999)
Inhibitory function of secretory leukocyte proteinase inhibitor (SLPI) in human saliva is HIV-1 specific and varies with virus tropism (2002)
Saliva and inhibition of HIV-1 infection: molecular mechanisms (2002)
Oral mucosal immunity and HIV infection: current status (2002)
Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk (2002)
Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons (2004)
Salivary secretory leukocyte protease inhibitor increases in HIV infection (2004)
Oral transmission of HIV, reality or fiction? An update (2006)
Comparison of human immunodeficiency virus type 1-specific inhibitory activities in saliva and other human mucosal fluids (2006)
HIV-1 neutralizing activity is correlated with increased levels of chemokines in saliva of HIV-1-exposed uninfected individuals (2008)
The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane (2009)
Those are all some very interesting reads, and sounds quite a bit like I remember reading. The article I read was more about the research, how it was found, and how the enzyme/protein attacked and killed the HIV virus.